Buffalo Bills 2024 Schedule
| AFC EAST |
| Matchup | Result/Time | ||
| Week 1 | Sun Sep 8, 2024 |  Arizona Cardinals | W, 34-28 |
| Week 2 | Thu Sep 12, 2024 | @  Miami Dolphins | W, 31-10 |
| Week 3 | Mon Sep 23, 2024 |  Jacksonville Jaguars | W, 47-10 |
| Week 4 | Sun Sep 29, 2024 | @  Baltimore Ravens | L, 35-10 |
| Week 5 | Sun Oct 6, 2024 | @  Houston Texans | L, 23-20 |
| Week 6 | Mon Oct 14, 2024 | @  New York Jets | W, 23-20 |
| Week 7 | Sun Oct 20, 2024 |  Tennessee Titans | W, 34-10 |
| Week 8 | Sun Oct 27, 2024 | @  Seattle Seahawks | W, 31-10 |
| Week 9 | Sun Nov 3, 2024 | Miami Dolphins | W, 30-27 |
| Week 10 | Sun Nov 10, 2024 | @  Indianapolis Colts | W, 30-20 |
| Week 11 | Sun Nov 17, 2024 |  Kansas City Chiefs | 4:25 PM |
| Week 13 | Sun Dec 1, 2024 |  San Francisco 49ers | 8:20 PM |
| Week 14 | Sun Dec 8, 2024 | @  Los Angeles Rams | 4:25 PM |
| Week 15 | Sun Dec 15, 2024 | @  Detroit Lions | 4:25 PM |
| Week 16 | Sun Dec 22, 2024 |  New England Patriots | 1:00 PM |
| Week 17 | Sun Dec 29, 2024 | New York Jets | 1:00 PM |
| Week 18 | Sun Jan 5, 2025 | @ New England Patriots | 12:00 AM |