Iowa State Cyclones 2024 Schedule
| BIG-12 |
| Matchup | Result/Time | ||
| Week 1 | Sat Aug 31, 2024 | North Dakota | W, 21-3 |
| Week 2 | Sat Sep 7, 2024 | @  Iowa | W, 20-19 |
| Week 4 | Sat Sep 21, 2024 |  Arkansas State | W, 52-7 |
| Week 5 | Sat Sep 28, 2024 | @  Houston | W, 20-0 |
| Week 6 | Sat Oct 5, 2024 |  Baylor | W, 43-21 |
| Week 7 | Sat Oct 12, 2024 | @  West Virginia | W, 28-16 |
| Week 8 | Sat Oct 19, 2024 |  UCF | W, 38-35 |
| Week 10 | Sat Nov 2, 2024 |  Texas Tech | L, 23-22 |
| Week 11 | Sat Nov 9, 2024 | @  Kansas | L, 45-36 |
| Week 12 | Sat Nov 16, 2024 |  Cincinnati | W, 34-17 |
| Week 13 | Sat Nov 23, 2024 | @  Utah | W, 31-28 |
| Week 14 | Sat Nov 30, 2024 |  Kansas State | W, 29-21 |
| Week 15 | Sat Dec 7, 2024 | @  Arizona State | L, 45-19 |