Iowa State Cyclones 2025 Schedule
BIG-12
| Matchup | Result/Time | ||
| Wk 1 | Sat 8/23 | 
Kansas State
KANST
| W, 24-21 |
| Wk 1 | Sat 8/30 | South Dakota SDAK | W, 55-7 |
| Wk 2 | Sat 9/6 | 
Iowa
IOWA
| W, 16-13 |
| Wk 3 | Sat 9/13 | @ 
Arkansas State
ARKST
| W, 24-16 |
| Wk 5 | Sat 9/27 | 
Arizona
ARZ
| W, 39-14 |
| Wk 6 | Sat 10/4 | @ 
Cincinnati
CIN
| L, 38-30 |
| Wk 7 | Sat 10/11 | @ 
Colorado
COL
| L, 24-17 |
| Wk 9 | Sat 10/25 | 
BYU
BYU
| L, 41-27 |
| Wk 10 | Sat 11/1 | 
Arizona State
ARZST
| L, 24-19 |
| Wk 11 | Sat 11/8 | @ 
TCU
TCU
| W, 20-17 |
| Wk 13 | Sat 11/22 | 
Kansas
KAN
| W, 38-14 |
| Wk 14 | Sat 11/29 | @ 
Oklahoma State
OKST
| W, 20-13 |