Louisville Cardinals 2025 Schedule
ACC
| Matchup | Result/Time | ||
| Wk 1 | Sat 8/30 | Eastern Kentucky Eastern Kentucky | W, 51-17 |
| Wk 2 | Fri 9/5 | 
James Madison
James Madison
| W, 28-14 |
| Wk 4 | Sat 9/20 | 
Bowling Green
Bowling Green
| W, 40-17 |
| Wk 5 | Sat 9/27 | @ 
Pittsburgh
Pittsburgh
| W, 34-27 |
| Wk 6 | Sat 10/4 | 
Virginia
Virginia
| L, 30-27 |
| Wk 8 | Fri 10/17 | @ 
Miami
Miami
| W, 24-21 |
| Wk 9 | Sat 10/25 | 
Boston College
Boston College
| W, 38-24 |
| Wk 10 | Sat 11/1 | @ 
Virginia Tech
Virginia Tech
| W, 28-16 |
| Wk 11 | Sat 11/8 | 
California
California
| L, 29-26 |
| Wk 12 | Fri 11/14 | 
Clemson
Clemson
| L, 20-19 |
| Wk 13 | Sat 11/22 | @ 
SMU
SMU
| L, 38-6 |
| Wk 14 | Sat 11/29 | 
Kentucky
Kentucky
| W, 41-0 |