Pittsburgh Panthers 2025 Schedule
ACC
| Matchup | Result/Time | ||
| Wk 1 | Sat 8/30 | Duquesne Duquesne | W, 61-9 |
| Wk 2 | Sat 9/6 | 
Central Michigan
Central Michigan
| W, 45-17 |
| Wk 3 | Sat 9/13 | @ 
West Virginia
West Virginia
| L, 31-24 |
| Wk 5 | Sat 9/27 | 
Louisville
Louisville
| L, 34-27 |
| Wk 6 | Sat 10/4 | 
Boston College
Boston College
| W, 48-7 |
| Wk 7 | Sat 10/11 | @ 
Florida State
Florida State
| W, 34-31 |
| Wk 8 | Sat 10/18 | @ 
Syracuse
Syracuse
| W, 30-13 |
| Wk 9 | Sat 10/25 | 
North Carolina State
North Carolina St...
| W, 53-34 |
| Wk 10 | Sat 11/1 | @ 
Stanford
Stanford
| W, 35-20 |
| Wk 12 | Sat 11/15 | 
Notre Dame
Notre Dame
| L, 37-15 |
| Wk 13 | Sat 11/22 | @ 
Georgia Tech
Georgia Tech
| W, 42-28 |
| Wk 14 | Sat 11/29 | 
Miami
Miami
| L, 38-7 |