Michigan State Spartans 2025 Schedule
BIG-TEN
| Matchup | Result/Time | ||
| Wk 1 | Fri 8/29 | 
Western Michigan
Western Michigan
| W, 23-6 |
| Wk 2 | Sat 9/6 | 
Boston College
Boston College
| W, 42-40 |
| Wk 3 | Sat 9/13 | Youngstown State Youngstown State | W, 41-24 |
| Wk 4 | Sat 9/20 | @ 
USC
USC
| L, 45-31 |
| Wk 6 | Sat 10/4 | @ 
Nebraska
Nebraska
| L, 38-27 |
| Wk 7 | Sat 10/11 | 
UCLA
UCLA
| L, 38-13 |
| Wk 8 | Sat 10/18 | @ 
Indiana
Indiana
| L, 38-13 |
| Wk 9 | Sat 10/25 | 
Michigan
Michigan
| L, 31-20 |
| Wk 10 | Sat 11/1 | @ 
Minnesota
Minnesota
| L, 23-20 |
| Wk 12 | Sat 11/15 | 
Penn State
Penn State
| L, 28-10 |
| Wk 13 | Sat 11/22 | @ 
Iowa
Iowa
| L, 20-17 |
| Wk 14 | Sat 11/29 | 
Maryland
Maryland
| W, 38-28 |