Colorado Buffaloes 2025 Schedule
BIG-12
| Matchup | Result/Time | ||
| Wk 1 | Fri 8/29 | 
Georgia Tech
Georgia Tech
| L, 27-20 |
| Wk 2 | Sat 9/6 | 
Delaware
Delaware
| W, 31-7 |
| Wk 3 | Fri 9/12 | @ 
Houston
Houston
| L, 36-20 |
| Wk 4 | Sat 9/20 | 
Wyoming
Wyoming
| W, 37-20 |
| Wk 5 | Sat 9/27 | 
BYU
BYU
| L, 24-21 |
| Wk 6 | Sat 10/4 | @ 
TCU
TCU
| L, 35-21 |
| Wk 7 | Sat 10/11 | 
Iowa State
Iowa State
| W, 24-17 |
| Wk 9 | Sat 10/25 | @ 
Utah
Utah
| L, 53-7 |
| Wk 10 | Sat 11/1 | 
Arizona
Arizona
| L, 52-17 |
| Wk 11 | Sat 11/8 | @ 
West Virginia
West Virginia
| L, 29-22 |
| Wk 13 | Sat 11/22 | 
Arizona State
Arizona State
| L, 42-17 |
| Wk 14 | Sat 11/29 | @ 
Kansas State
Kansas State
| L, 24-14 |