San Francisco 49ers Odds
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| SCORE | SPREAD | MONEYLINE | O/U | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AWAY | HOME | WK | DATE | AWAY | HOME | AWAY | PAY | HOME | PAY | COV | AWAY | HOME | O/U | O$ | U$ |
| 1 | Sun Sep 7, 2025 | 17 | 13 | -2.0 | -112 | +2.0 | -109 | -134 | +114 | 43.5 | -108 | -110 | |||
| 2 | Sun Sep 14, 2025 | 26 | 21 | -3.0 | -108 | +3.0 | -112 | -161 | +136 | 40.5 | -111 | -110 | |||
| 3 | Sun Sep 21, 2025 | 15 | 16 | +1.5 | -111 | -1.5 | -110 | +103 | -123 | 44.5 | -109 | -112 | |||
| 4 | Sun Sep 28, 2025 | 26 | 21 | +3.5 | -121 | -3.5 | -101 | +146 | -173 | 45.5 | -111 | -111 | |||
| 5 | Thu Oct 2, 2025 | 26 | 23 | +8.5 | -112 | -8.5 | -107 | +351 | -445 | 44.0 | -112 | -109 | |||
| 6 | Sun Oct 12, 2025 | 19 | 30 | +3.5 | -113 | -3.5 | -106 | +157 | -186 | 47.0 | -109 | -112 | |||
| 7 | Sun Oct 19, 2025 | 10 | 20 | -1.0 | -109 | +1.0 | -109 | -112 | -106 | 46.5 | -110 | -111 | |||
| 8 | Sun Oct 26, 2025 | 15 | 26 | +3.0 | -111 | -3.0 | -109 | +134 | -157 | 41.0 | -108 | -109 | |||
| 9 | Sun Nov 2, 2025 | 34 | 24 | -2.5 | -112 | +2.5 | -108 | -140 | +120 | 47.5 | -112 | -109 | |||
| 10 | Sun Nov 9, 2025 | 42 | 26 | -6.0 | -108 | +6.0 | -111 | -262 | +215 | 49.5 | -108 | -112 | |||
| 11 | Sun Nov 16, 2025 | 41 | 22 | -3.5 | -107 | +3.5 | -112 | -190 | +160 | 48.5 | -112 | -108 | |||
| 12 | Mon Nov 24, 2025 | 9 | 20 | +7.5 | -114 | -7.5 | -104 | +310 | -392 | 49.0 | -109 | -111 | |||
| 13 | Sun Nov 30, 2025 | 26 | 8 | -5.0 | -112 | +5.0 | -110 | -250 | +205 | 35.0 | -112 | -110 | |||
| 15 | Sun Dec 14, 2025 | +12.5 | -110 | -12.5 | -112 | +628 | -992 | 43.5 | -114 | -109 | |||||
| 16 | Mon Dec 22, 2025 | -3.0 | -115 | +3.0 | -105 | -166 | +140 | 46.5 | -110 | -110 | |||||
| 17 | Sun Dec 28, 2025 | +3.5 | -110 | -3.5 | -110 | +164 | -198 | 46.5 | -110 | -110 | |||||
| 18 | Sun Jan 4, 2026 | +4.5 | -110 | -4.5 | -110 | +180 | -218 | 44.5 | -115 | -105 | |||||