San Francisco 49ers Depth Chart
- NFC West
- Stadium
- Levi's Stadium
- Head Coach
- Kyle Shanahan
- Offensive Coordinator
- Kyle Shanahan
- Defensive Coordinator
- Robert Saleh
- Special Teams Coach
- Richard Hightower
- Defensive Scheme
- 4-3
San Francisco 49ers wide receiver Deebo Samuel (hamstring) practiced all week and was taken off the final injury report, meaning he will return for Week 12 against the division-rival Rams. Samuel will be returning for the first time since Week 7, which is great news for a banged-up 49ers offense that will likely once again be without rookie Brandon Aiyuk, who tested positive for COVID-19. But the 24-year-old Samuel will be taking throws from backup Nick Mullens and will likely face All-Pro cornerback Jalen Ramsey in coverage in his first game back. That's not an ideal situation, even if Samuel had six catches for 66 yards and a touchdown against LA in their first meeting. You're best off taking a wait-and-see approach with Samuel, who should be considered a risky WR4/flex in his first game back.
San Francisco 49ers running back Tevin Coleman (knee) has been ruled out for Week 12 against the division-rival Rams. Raheem Mostert (ankle) and Jeff Wilson Jr. (ankle) will be activated from Injured Reserve on Saturday and are expected to play on Sunday, joining Jerick McKinnon in a crowded backfield. Mostert was the leader of this backfield before his injury, but head coach Kyle Shanahan could change things up in what is becoming a big headache for fantasy managers. Coleman may not even have much of a role when he returns to action, making him droppable for better options in shallow leagues. If Mostert is active, he'll be a shaky WR3/flex against a tough Rams defensive line.
San Francisco 49ers running backs Raheem Mostert (ankle) and Jeff Wilson Jr. (ankle) and cornerback Richard Sherman (calf) will be activated from Injured Reserve on Saturday and will be questionable for Week 12 against the Rams. Mostert has been out since Week 6 but could be inserted back into the lead-back role, albeit in a crowded backfield, if he's active on Sunday. He will certainly be a nice addition to fantasy lineups that are trying to make a postseason run, but Mostert will be a somewhat shaky RB3/flex if he's eased back into the fold in a crowded backfield against a Rams Defense allowing the fourth-fewest fantasy points to RBs in 2020. Wilson has been out since Week 7 but was effective when asked to step up for San Fran. Mostert will be the most attractive fantasy back on the Niners if he plays, but this backfield will still be a headache for fantasy managers in Week 12.
The 49ers Defense has been pummeled over their last three games. Each of their past three opponents have scored at least 27 points on them, with two of them topping 30. This week, the 49ers are coming off a bye to face the Los Angeles Rams. The 49ers held the Rams to just 16 points in their previous matchup this year. However, the Rams are coming off a strong offensive showing where they scored 27 points against the Tampa Bay Buccaneers. This week's game shouldn't be super high-scoring and both teams will likely run the ball a lot, which will slow the pace of the game. If you're in a bind, you can do worse than starting the 49ers as a low-end option, but you might be able to find better options on the waiver wire.
San Francisco 49ers tight end Jordan Reed (illness) has been held out of practice the past few days while dealing with an illness that is not COVID-related. He is currently listed as questionable for this week's game against the Los Angeles Rams. If he's able to go this week, he should be in line for a decent workload, but it will be against a tough matchup. The Rams have an elite pass defense, allowing just 200.6 passing yards per game, which ranks second in the league. If he's active, he's a low-end TE1 option who is safer in PPR leagues. He should see around eight targets as he and Deebo Samuel (hamstring) figure to be the top pass-catching options for quarterback Nick Mullens.