San Francisco 49ers 2025 Schedule
NFC WEST
| Matchup | Result/Time | ||
| Wk 1 | Sun 9/7 | @ 
Seattle Seahawks
Seahawks
| W, 17-13 |
| Wk 2 | Sun 9/14 | @ 
New Orleans Saints
Saints
| W, 26-21 |
| Wk 3 | Sun 9/21 | 
Arizona Cardinals
Cardinals
| W, 16-15 |
| Wk 4 | Sun 9/28 | 
Jacksonville Jaguars
Jaguars
| L, 26-21 |
| Wk 5 | Thu 10/2 | @ 
Los Angeles Rams
Rams
| W, 26-23 |
| Wk 6 | Sun 10/12 | @ 
Tampa Bay Buccaneers
Buccaneers
| L, 30-19 |
| Wk 7 | Sun 10/19 | 
Atlanta Falcons
Falcons
| W, 20-10 |
| Wk 8 | Sun 10/26 | @ 
Houston Texans
Texans
| L, 26-15 |
| Wk 9 | Sun 11/2 | @ 
New York Giants
Giants
| W, 34-24 |
| Wk 10 | Sun 11/9 |
Los Angeles Rams
Rams
| L, 42-26 |
| Wk 11 | Sun 11/16 | @
Arizona Cardinals
Cardinals
| W, 41-22 |
| Wk 12 | Mon 11/24 | 
Carolina Panthers
Panthers
| W, 20-9 |
| Wk 13 | Sun 11/30 | @ 
Cleveland Browns
Browns
| W, 26-8 |
| Wk 15 | Sun 12/14 | 
Tennessee Titans
Titans
| 4:25 PM |
| Wk 16 | Mon 12/22 | @ 
Indianapolis Colts
Colts
| 8:15 PM |
| Wk 17 | Sun 12/28 | 
Chicago Bears
Bears
| 8:20 PM |
| Wk 18 | Sun 1/4 |
Seattle Seahawks
Seahawks
| 12:00 AM |