Isaac Guerendo Fantasy Stats

San Francisco 49ers running back Isaac Guerendo (ankle, knee) has been taking part in voluntary organized team activities this spring after injuring his MCL and spraining his ankle in the Week 18 regular-season finale last year. Guerendo, a fourth-round pick (129th overall) in 2024, should be a full-go for the start of mandatory minicamp on June 10. All-Pro Christian McCaffrey (knee) is also back and ready to roll after missing the majority of the 2024 campaign, so Guerendo will enter the 2025 season as the backup, but Jordan Mason was traded to the Minnesota Vikings and Elijah Mitchell left in free agency. The 24-year-old Guerendo had 5.0 yards per carry on his 84 rushing attempts last year for 420 yards and four touchdowns in 16 games (three starts), adding 15 catches for 152 yards through the air. Consider him a high-upside handcuff behind the injury-prone CMC.

An MRI exam on Monday morning revealed that San Francisco 49ers rookie running back Isaac Guerendo (ankle, knee) suffered an MCL sprain and an ankle sprain in the loss to the division-rival Arizona Cardinals on Sunday in the Week 18 regular-season finale, according to a source. Guerendo will have plenty of time to heal up in the offseason, and the best news is that he didn't suffer any damage to his ACL. Both of the injuries are to his left leg. The 24-year-old fourth-round pick didn't see much of an opportunity in 2024 until late in the season when both Christian McCaffrey (knee) and Jordan Mason (ankle) were ruled out for the year, but when he did get his chances, he was pretty effective out of the Niners' backfield. Guerendo finished with 5.0 yards per carry for 420 yards and four TDs on 84 carries through 16 games. He should serve as valuable insurance for McCaffrey in 2025.

Per head coach Kyle Shanahan, San Francisco 49ers running back Isaac Guerendo (knee, ankle) has likely picked up an MCL sprain but will undergo more testing on Monday to confirm the severity of the injury. Matt Barrows of The Athletic reported the news. That'd be a best-case scenario for the rookie, who was carted off in the first quarter of his team's 47-24 loss to the Arizona Cardinals. Guerendo was bent up awkwardly not even two minutes into the contest and quickly ruled out afterward. San Francisco has been unable to keep a running back healthy this season, as they've had four suffer serious injuries. It's been a disappointing year for the 49ers -- a team with Super Bowl aspirations that won't make a playoff appearance in 2024 after a campaign riddled with injuries. They'll hope for better in 2025.

San Francisco 49ers running back Isaac Guerendo (knee, ankle) exited during the first quarter of Sunday's Week 18 game against the Arizona Cardinals. He has been ruled out for the remainder of the contest. It was an ugly scene in Arizona as Guerendo's leg bent awkwardly while he was being tackled. He was in noticeable pain while being carted off the field, and the 49ers ruled him out with both knee and ankle injuries very quickly. He finishes Sunday's contest with two carries for five yards. All in all, he registered 420 rushing yards, 152 receiving yards, and four total touchdowns while splitting time as a depth option and starter this season. Patrick Taylor Jr. will lead the 49ers' backfield for the remainder of Sunday's contest.

San Francisco 49ers rookie running back Isaac Guerendo (foot, hamstring) is off the injury report and ready to roll for a Week 18 matchup with the Cardinals in Arizona. Last week at home versus Detroit, Guerendo took just nine carries for 34 yards but snagged all four targets in the passing game for 65 yards. Arizona's defense represents a favorable opportunity for Guerendo to finish his first NFL campaign on a high note -- they have allowed the 10th-most half-PPR points per game (21.9). Last week, they allowed 14.7 points to Kyren Williams of the Los Angeles Rams. With the 49ers having been eliminated from playoff contention weeks ago and playing their final game of 2024, head coach Kyle Shanahan should give Guerendo his classic heavy lead-back usage while assessing Guerendo's role in 2025. This could be especially true with the 49ers injury issues -- backup Joshua Dobbs is starting for an injured Brock Purdy (right elbow), wideout Deebo Samuel Sr. (rib, wrist) is out, and tight end George Kittle (ankle, hamstring) is questionable. Guerendo is a back-end RB1 in Week 18.

San Francisco 49ers rookie running back Isaac Guerendo had a useful fantasy day during a 40-34 loss to the Detroit Lions on Monday night. The former high school wide receiver took nine carries for just 34 yards but saved his day through the air by catching all four of his targets for 65 yards. With most fantasy leagues in the books after Monday night, it's fair to say that Guerendo comported himself well in his rookie season by flashing the speed, receiving chops, and scheme fit that caused the 49ers to trade up and select him in the fourth round. Guerendo figures to draw another start while vying for his fifth 10-plus-point half-PPR performance in Week 18's meaningless game in Arizona.

San Francisco 49ers rookie running back Isaac Guerendo (foot, hamstring) will return from a one-week absence when the team hosts the Detroit Lions on Monday night. Before missing last week's contest against Miami, Guerendo took 16 carries for 57 yards and caught four of four targets for 18 yards versus the Rams. The week before that, the fourth-rounder out of Louisville popped off for 25.8 half-PPR points against Chicago. Detroit has a quality rush defense, having allowed the fourth-fewest points per game to opposing running backs this season. Most recently, they held the Bears to 59 yards and no touchdowns on the ground. It's worth noting that San Francisco is down to their third-string left tackle and could be missing starting right tackle Colton McKivitz (knee), who is questionable. Consider Guerendo a back-end RB2 in Week 17.

According to Adam Schefter of ESPN, San Francisco 49ers rookie running back Isaac Guerendo (hamstring/foot) is expected to play on Monday evening. The rookie running back was unable to suit up last weekend and has logged two limited practice sessions earlier this week. Fantasy managers should keep a close eye on his status on Saturday's final injury report as a full practice session may help him avoid an injury designation. While sidelined, Patrick Taylor Jr. was given the starting nod and tallied just 24 yards on eight attempts. Guerendo has averaged a solid 19.1 PPR points per game during Weeks 14 and 15 and should be viewed as an RB2 if he is able to suit up on Monday, despite facing a tough Detroit run defense that has allowed the fourth-fewest PPR to the position.

San Francisco 49ers rookie running back Isaac Guerendo (foot, hamstring) was limited in practice for the second straight day this week on Friday. Guerendo, who did not play in the Week 16 loss to the Miami Dolphins, may need to upgrade to a full practice on Saturday to avoid carrying a questionable designation into Monday night's Week 17 showdown in what will be a rematch of last year's NFC Championship against the Detroit Lions. If the 24-year-old back is feeling good enough to play on Monday, he should return to lead-back duties for San Fran, albeit in a bad matchup. Although they are pretty banged up now, the Lions defense has allowed the fourth-fewest half-PPR points per game to RBs in 15 games in 2024. However, in the last five weeks, they've been in the middle of the pack in that same category. If Guerendo is active in Week 17, he'll be a low-end RB2/high-end RB3/flex in fantasy.

San Francisco 49ers rookie running back Isaac Guerendo (foot, hamstring) is limited in the team's first practice of the week on Thursday. Guerendo is dealing with two injuries and was unable to play in the Week 16 loss to the Miami Dolphins. It's good news that the 24-year-old is back on the practice field, but he might need to upgrade to a full practice in the next two days to avoid a questionable tag heading into a Monday night game against the Detroit Lions. Guerendo will operate as San Fran's lead back if he's available this week, but the problem is it might not be worth the risk leaving him in starting lineups for championship week in fantasy if he's uncertain to play on Monday night. Additionally, the matchup against Detroit's defense is not a friendly one for fantasy purposes. If Guerendo misses a second straight game, Patrick Taylor Jr. would be in line for a second straight start.