Isaac Guerendo Fantasy Stats

San Francisco 49ers running back Isaac Guerendo has emerged as a potential drop candidate as dynasty managers prepare for the offseason roster crunch. Between clearing taxi squad spots, adding players, and navigating rookie drafts, dynasty managers may need to make decisions about which rostered players to cut. Guerendo is a prime candidate after an underwhelming second season with the 49ers in 2025. He appeared in 14 games but played exclusively on special teams, never logging an offensive snap. He was buried on the depth chart behind Christian McCaffrey, Brian Robinson Jr., Jordan James, and even fullback Kyle Juszczyk. It was a surprising, harsh development for the Louisville product after he finished as the overall RB48 in PPR leagues with 572 scrimmage yards and five touchdowns in 2024. Evidently, the 49ers don't see Guerendo in their long-term plans, and it's hard to imagine he'll climb the depth chart in 2026, even with Robinson expected to hit free agency. Managers in most dynasty leagues should feel comfortable dropping the 25-year-old.

San Francisco 49ers running back Jordan James is active for Monday's Week 16 contest against the Indianapolis Colts and is on track to make his NFL debut. The rookie had previously been a healthy scratch, but he's getting a chance to play on primetime television, perhaps in a mix of special teams and offensive depth roles. He's taking the spot of fellow rookie Isaac Guerendo, who is a healthy scratch for the first time in his young career. Guerendo has contributed on special teams this year, but he doesn't have an offensive snap yet. Both running backs remain buried on the depth chart behind Christian McCaffrey and Brian Robinson Jr.

San Francisco 49ers running back Isaac Guerendo was thrust into action in his rookie season in the NFL in 2024 because Christian McCaffrey missed most of the year due to injuries. Guerendo finished with 84 rushing attempts for 420 yards and four touchdowns in 16 games (three starts) and also chipped in 15 catches on 16 targets as a pass-catcher for 152 yards. Fantasy managers probably viewed him as a pretty valuable handcuff for the injury-prone CMC going into 2025 drafts, but the Niners' acquisition of Brian Robinson Jr. before the season pretty much killed whatever fantasy appeal he had. Through the first seven weeks of his sophomore campaign, the 25-year-old former fourth-rounder has yet to play an offensive snap with CMC and B-Rob both staying healthy. Instead, Guerendo has been limited to a special teams role, returning five kickoffs for a combined 100 yards.

San Francisco 49ers running back Isaac Guerendo recorded 572 yards from scrimmage and four touchdowns on 99 total touches as a rookie in 2024. However, through five games in 2025, the 25-year-old has not played a single offensive snap. Guerendo is buried on the 49ers running back depth chart behind Christian McCaffrey and Brian Robinson Jr. As long as both McCaffrey and Robinson Jr. remain healthy, it appears unlikely that Guerendo's role in San Francisco's offense is going to change. Guerendo maintains some appeal in dynasty leagues, but he should remain off the radar of redraft fantasy managers for the time being.

San Francisco 49ers running back Isaac Guerendo has yet to see an offensive snap in 2025, and there is little reason to expect that to change in Week 4. Christian McCaffrey is the team's unquestioned starter, and Brian Robinson Jr. has the second position on the depth chart locked down. The team's official depth chart lists both Guerendo and rookie Jordan James as the third-string running back, raising the question of which of the two would be given an opportunity in the backfield should the need arise. In the meantime, Guerendo has been relegated to kick return duty. Through three games, he has taken back four kicks for a grand total of 82 yards. Until an injury shakes up the depth chart, Guerendo has no place on fantasy football rosters.

San Francisco 49ers running back Isaac Guerendo entered the 2025 season as a prime handcuff for fantasy managers who were looking to score Christian McCaffrey at a discount early in drafts. However, Guerendo's fantasy value took a massive hit when the Niners acquired Brian Robinson Jr. from the Washington Commanders. B-Rob has been McCaffrey's backup through two weeks, relegating Guerendo to a distant RB3 role. In the Week 2 win over the New Orleans Saints, the 25-year-old didn't play a single snap on offense, with all 17 of his snaps coming on special teams. Guerendo averaged a healthy 5.0 yards per carry on 84 rushing attempts for 420 yards and four touchdowns in 16 games (three starts) as a rookie in 2024 when CMC was bothered by injuries, but currently, he's well off the fantasy radar in single-year leagues going into Week 3 against the division-rival Arizona Cardinals.

Second-year running back Isaac Guerendo opens the season third on the 49ers' depth chart, though he may already see more action than originally anticipated. Christian McCaffrey (calf) popped up on the team's injury report this week and is tagged as questionable for San Francisco's Week 1 matchup against the Seahawks. Guerendo's only route to fantasy relevance relies on CMC sitting. If that does happen, then he can be seen as a deep-league flex candidate. Brian Robinson Jr. will likely draw the start, but Guerendo made his mark in 2024 in similar circumstances and is a potential RB4/5 pending McCaffrey's status.

San Francisco 49ers running back Isaac Guerendo (shoulder) played at less than 100 percent during Saturday's preseason contest. Guerendo started the game, but re-aggravated his shoulder injury in the first quarter. Luckily, Guerendo was able to return to the game after getting looked at on the sideline. At the moment, all signs point to Guerendo being available for the season opener. However, his fantasy value is going to take a serious hit with Brian Robinson Jr. taking over as the RB2 in San Francisco. Guerendo probably won't see significant snaps unless someone gets hurt in the backfield.

Running back Christian McCaffrey is the San Francisco 49ers' unquestioned No. 1 RB when he's healthy, but Cam Inman of the Bay Area News Group thinks that Isaac Guerendo is still the projected RB2 behind CMC despite Friday's trade acquisition of Brian Robinson Jr, presuming that B-Rob isn't fast-tracked over the next two weeks. Guerendo resumed practicing this week after two weeks off from a shoulder dislocation, so he should be ready for Week 1 of the regular season against the division-rival Seattle Seahawks on Sunday, Sept. 7. Although the 25-year-old Guerendo figures to be the RB2 to open the year, it's entirely possible that Robinson leaps him on the RB depth chart eventually. The trade for B-Rob definitely is a hit to Guerendo's potential upside if CMC gets hurt again, too. Early on, Robinson will most likely be more of a short-yardage/goal-line power back in his new home.

San Francisco 49ers running back Isaac Guerendo (shoulder) returned to training camp practice on Tuesday and was pretty active, according to Matt Maiocco of NBC Sports Bay Area. Guerendo will have more opportunities for reps with both Patrick Taylor Jr. (shoulder) and Corey Kiner (ankle) both injured. The 25-year-old missed a couple of weeks at camp with a shoulder injury but is now back in time to be ready for the Week 1 regular-season opener in two weeks. It remains to be seen if the Niners will play him in the preseason finale against the Los Angeles Chargers on Saturday. Guerendo, a fourth-rounder last year, had a healthy 5.0 yards per carry and 420 rushing yards on 84 carries in 16 games (three starts) in his first season in the NFL. He's primarily a handcuff option for the injury-prone Christian McCaffrey, but if CMC misses more time with injury, Guerendo would be an every-week fantasy starter.